It main differences are in the technique and the areas of placement. The injections are done with a blunt needle called a cannula that means there is almost no bruising and relatively pain-free as it glides under the skin to position the product. The product is then deposited in a fan like shape to create a mesh of product that ultimately acts are little growth plates for your collagen. Typically this is injected into the side of the face so that the tightening here creates a domino effect of tightening further forward on the face. HArmonyCa® is administered into the skin superficially. So, it is safe and comes with minimal discomfort. Injection site bruising is highly unlikely, but it can happen. Commonly occurring minimal side effects (redness, swelling, pain, tenderness and itching) are manageable and self-limiting.