The risks of polynucleotides are less than those of other injectable procedures, but this will depend on the practitioner’s experience and technique. However, unlike dermal filler, the treatment cannot be reversed as the product can’t be dissolved. Side effects of polynucleotides are generally minimal, with the main potential side effects relating to the site of the injection, where patients may experience redness, swelling and bruising which should settle after one to two days. More serious side effects, such as allergic reactions, are extremely rare. As with all treatments, it’s important to carry out a thorough pre-treatment consultation to assess the patient’s suitability.