Before the treatment a numbing cream can be applied to the patient, especially if there are multiple injections involved. Depending on the area of treatment, the polynucleotides can be injected via two methods. The first are very tiny needles, leaving tiny blebs on the surface which disappear usually after a few hours. Alternatively, a blunt-ended cannula may be used to spread the product evenly. The process usually takes about 20-30 minutes.