Skin growths such as cysts and lipomas are both frequent and can look similar in many ways, so how can you distinguish between the two? One way to try and tell the difference between cysts and lipomas by touch. When you apply pressure to a cyst, it does not move in the same way, as a cyst is contained in a 'sac'. Lipomas are easy to move and sensitive to touch if they push against a nerve or blood artery, but they seldom cause issues. Neither lipomas nor cysts should hurt, although they may feel sensitive when you probe them. Although both are most likely harmless, they should be diagnosed and treated by a doctor.